Onder andere met: Ben Stiller (Alex (voice)), Chris Rock (Marty / Additional Zebras (voice)), David Schwimmer (Melman (voice)), Jada Pinkett Smith (Gloria (voice)), Sacha Baron Cohen (Julien (voice)), Cedric the Entertainer (Maurice (voice)), Andy Richter (Mort (voice)), Bernie Mac (Zuba (voice)), Alec Baldwin (Makunga (voice)), Sherri Shepherd (Mom (voice)), Will i Am (Moto Moto (voice) (as Will.I.Am)), Elisa Gabrielli (Nana (voice)), Tom McGrath (Skipper / Lemur #1 (voice)), Chris Miller (Kowalski (voice)), Christopher Knights (Private (voice))