Onder andere met: Hugh Jackman (Logan / Wolverine), Liev Schreiber (Victor Creed / Sabretooth), Danny Huston (William Stryker), Will i Am (John Wraith), Lynn Collins (Kayla Silverfox), Kevin Durand (Frederick J. Dukes / The Blob), Dominic Monaghan (Chris Bradley / Bolt), Taylor Kitsch (Remy LeBeau / Gambit), Daniel Henney (David North / Agent Zero), Ryan Reynolds (Wade Wilson / Deadpool), Scott Adkins (Weapon XI), Tim Pocock (Scott Summers), Julia Blake (Heather Hudson), Max Cullen (Travis Hudson), Troye Sivan (Young James Logan), Alice Parkinson (Elizabeth Howlett)