Onder andere met: Bruce Willis (Major Korben Dallas), Gary Oldman (Jean-Baptiste Emanuel Zorg), Ian Holm (Priest Vito Cornelius), Milla Jovovich (Leeloo), Chris Tucker (DJ Ruby Rhod), Luke Perry (Billy), Brion James (General Munro), Tom `Tiny` Lister Jr. (President Lindberg (as Tommy `Tiny` Lister Jr.)), Lee Evans (Fog), Charlie Creed-Miles (David (as Charlie Creed Miles)), Tricky (Right Arm), John Neville (General Staedert), John Bluthal (Professor Pacoli), Mathieu Kassovitz (Mugger), Christopher Fairbank (Mactilburgh)