Onder andere met: Kyle MacLachlan (Jeffrey Beaumont), Isabella Rossellini (Dorothy Vallens), Dennis Hopper (Frank Booth), Laura Dern (Sandy Williams), Hope Lange (Mrs. Williams), Dean Stockwell (Ben), George Dickerson (Detective Williams), Priscilla Pointer (Mrs. Beaumont), Frances Bay (Aunt Barbara), Jack Harvey (Mr. Beaumont), Ken Stovitz (Mike), Brad Dourif (Raymond), Dick Green (Don Vallens), Fred Pickler ("Yellow Man"/Det. T.R Gordon)