Onder andere met: Nicolas Cage (Frank Pierce), Patricia Arquette (Mary Burke), John Goodman (Larry), Ving Rhames (Marcus), Tom Sizemore (Tom Wolls), Marc Anthony (Noel), Mary Beth Hurt (Nurse Constance), Cliff Curtis (Cy Coates), Nestor Serrano (Dr. Hazmat), Aida Turturro (Nurse Crupp), Sonja Sohn (Kanita), Cynthia Roman (Rose), Afemo Omilami (Griss), Cullen O. Johnson (Mr. Burke), Arthur J. Nascarella (Captain Barney), John Heffernan (Mr. Oh), Harper Simon (I.B. Bangin')