Onder andere met: Anthony Hopkins (Dr. Hannibal Lecter), Julianne Moore (Clarice Starling), Gary Oldman (Mason Verger), Ray Liotta (Paul Krendler), Frankie Faison (Barney Matthews), Giancarlo Giannini (Chief Inspector Rinaldo Pazzi), Francesca Neri (Allegra Pazzi), Željko Ivanek (Dr. Cordell Doemling), Hazelle Goodman (Evelda Drumgo), David Andrews (FBI Agent Pearsall), Francis Guinan (FBI Asst. Director Noonan), James Opher (DEA Agent John Eldridge), Enrico Lo Verso (Gnocco), Ivano Marescotti (Carlo Deogracias), Danielle de Niese (Beatrice)