Onder andere met: John Cusack (Craig Schwartz), Cameron Diaz (Lotte Schwartz), Catherine Keener (Maxine Lund), John Malkovich (John Horatio Malkovich), Orson Bean (Dr. Lester), Mary Kay Place (Floris), Ned Bellamy (Derek Mantini), Reginald C. Hayes (Don), Charlie Sheen (Charlie), Carlos Jacott (Larry the Agent), Richard Fancy (Johnson Heyward), Kelly Teacher (Emily), K.K. Dodds (Wendy), Byrne Piven (Captain Mertin), Judith Wetzell (Tiny Woman)