Onder andere met: Denzel Washington (Lincoln Rhyme), Angelina Jolie (Amelia Donaghy), Queen Latifah (Thelma), Ed O'Neill (Detective Sellito), Michael Rooker (Captain Cheney), Luiz Guzman (Detective Eddie Ortiz), Mike McGlone (Detective Kenny Solomon), Leland Orser (Richard Thompson), John Benjamin Hickey (Doctor Barry Lehman)